PPRTV Quickview New Search Select Chemical Acenaphthene Acenaphthylene Acetone Cyanohydrin Acetophenone Acrolein Acrylic Acid Adiponitrile Aldrin Alizarin Red Compounds Allyl Alcohol Aluminum Aluminum salts of inorganic phosphates Amino-2,6-Dinitrotoluene, 4- Amino-4,6-Dinitrotoluene, 2- Amino-4-chlorobenzotrifluoride, 3- Aminophenol, m- Aminophenol, o- Aminophenol, p- Aminopyridine, 4- Ammonia Ammonium Picrate Ammonium polyphosphate (APP) Amyl Alcohol, tert- Aniline Anilinobenzothiazole Anthracene Anthraquinone, 9,10- Antimony (metallic) Soluble Antimony Compounds (Antimony Potassium Tartrate) Antimony Trioxide Aroclor 5460 Azodicarbonamide Benz[a]anthracene Benzaldehyde Benzene Benzenediamine-2-methyl sulfate, 1,4- Benzenethiol Benzo[b]fluoranthene Benzo[e]pyrene (BeP) Benzo[k]fluoranthene Benzofluorene, 2,3- Benzoic Acid Benzothiazole Benzotrichloride Benzyl Chloride Benzyl alcohol Bifenox Biphenyl, 1,1'- Bis(2-chloro-1-methylethyl) ether Bis(2-chloroethoxy)methane Boron Trichloride Bromo-2-chloroethane, 1- Bromo-3-fluorobenzene, 1- Bromo-4-Ethylbenzene, 1- Bromo-4-fluorobenzene, 1- Bromoacetophenone, 3- Bromochloromethane Bromodichloromethane Bromodiphenyl Ether, 4- Bromoform Bromomethane Bromopyridine, 2- Butyl Formate, tert- Butyl alcohol, sec- Butyl benzyl phthalate Butylated hydroxytoluene Butylbenzene, n- Butylbenzene, sec- Butylbenzene, tert- Butyltin Compounds, Di- Butyltin Compounds, Mono- Butyltin Compounds, Tri- Calcium hydroxide phosphate Calcium pyrophosphate (CPP) Calcium salts of inorganic phosphates Carbazole Carbonyl Sulfide Chloro-2-methylaniline, 4- Chloro-3-Methylphenol, 4- (p-Chloro-m-cresol) Chloro-6-fluorophenol, 2- Chloroacetaldehyde, 2- Chloroacetic Acid Chloroaniline, p- Chlorobenzene Chlorobenzene sulfonic acid, p- Chlorobenzoic Acid, 2- Chlorobenzoic Acid, p- Chlorobenzotrifluoride, 3-nitro-4- Chlorobenzotrifluoride, 4- Chlorobutane, 1- Chlorobutane, 2- Chloroethane Chloroethanol, 2- Chloromethane Chloronaphthalene, 2- Chloronitrobenzene, o- Chloronitrobenzene, p- Chlorooctadecane, 1- Chlorophenol, 2- Chloropropane, 2- Chlorotoluene, o- Chlorotoluene, p- Chrysene Cobalt Complex Mixtures of Aliphatic and Aromatic Hydrocarbons Coronene Crotonaldehyde, trans- Cyanogen Bromide Cyclohexane Cyclohexanone Cyclohexene DDD, o,p'- DDD, p,p'- DDE, p,p'- DDT, o,p'- Decane, n- Diammonium phosphate (DAP) Dibenzofuran Dibenzothiophene Dibromo-3-Chloropropane, 1,2- Dibromobenzene, 1,3- Dibromochloromethane Dicalcium phosphate (DCP) Dichloro-2-butene, 1,4- Dichloro-2-butene, cis-1,4- Dichloro-2-butene, trans-1,4- Dichlorobenzophenone, 4,4'- Dichlorobenzotrifluoride, 3,4- Dichlorodifluoromethane Dichloroethane, 1,1- Dichloroethane, 1,2- Dichloroethylene, 1,2- (Mixed Isomers) Dichloroethylene, cis-1,2- Dichloroethylene, trans-1,2- Dichlorophenol, 2,4- Dichloropropane, 1,2- Dichloropropane, 1,3- Dichloropropane, 2,2- Dichloropropene, 1,1- Dicyclohexylamine Dicyclopentadiene Diethanolamine Diethyl phosphorodithioate, O, O- Diethylene Glycol Monobutyl Ether Diethylene Glycol Monoethyl Ether Diethylene Glycol Monomethyl Ether Diethylformamide Difluoropropane, 2,2- Diisopropyl Ether Diisopropyl Methylphosphonate Dimethoxybenzidine, 3,3'- Dimethyl Sulfide Dimethyl methylphosphonate Dimethylaniline, 2,4- Dimethylaniline, N,N- Dimethylbenzidine, 3,3'- Dimethylcyclohexylamine, n,n- Dimethylformamide Dimethylhydrazine, 1,1- Dimethylmercury Dimethylphenethylamine Dimethylphenol, 2,4- Dimethylphthalate Dinitro-o-cresol, 4,6- Dinitroaniline, 3,5- Dinitrobenzene, 1,2- Dinitrobenzene, 1,4- Dinitrophenol, 2,4- Dinitrosopentamethylenetetramine, N,N- Dinitrotoluene, 2,6- Dinitrotoluene, Technical grade Dinoseb Diphenyl Ether Diphenyl Sulfone Diphenyl-1,4-benzenediamine, N,N'- Diphenylamine Dipotassium phosphate Disodium phosphate Disulfoton Diundecyl Phthalate Endosulfan Endosulfan Sulfate Endrin Endrin aldehyde Endrin ketone Epichlorohydrin Ethoxyethanol Acetate Ethoxyethanol, 2- Ethyl Acetate Ethyl Acrylate Ethyl Ether Ethyl Methacrylate Ethylbenzene Ethylene Cyanohydrin Ethylene Diamine Ethylhexanol, 2- Fluoranthene Fluorene Fluorobenzene Fluorobiphenyl, 2- Fluorophenol, 2- Formic Acid Gadolinium Glycidaldehyde Guanidine Guanidine Chloride Guanidine Nitrate Heptanal, n- Heptane, N- Hexachlorobenzene Hexachlorobutadiene Hexachlorocyclohexane, Delta- Hexadecanoic Acid Hexamethylphosphoramide Hexane, Commercial Hexane, N- Hexanedioic Acid Hydrazine Hydroquinone Indeno[1,2,3-cd]pyrene Iodomethane Iron Sulfide Iron and Compounds Isobutyl Alcohol Isopropanol Isopropyltoluene, p- Lactonitrile Lanthanum Lanthanum Acetate Hydrate Lanthanum Chloride Heptahydrate Lanthanum Chloride, Anhydrous Lanthanum Nitrate Hexahydrate Lewisite Lithium Lutetium Malononitrile Mercaptobenzothiazole, 2- Mercuric Sulfide Metaphosphoric acid (HPO3), aluminum salt (3:1) [aluminum metaphosphate] Methacrylonitrile Methoxyethanol Acetate, 2- Methoxyethanol, 2- Methyl Acetate Methyl Acrylate Methyl Hydrazine Methyl Mercaptan Methyl Phosphonic Acid Methyl dicyclohexylamine, n- Methyl-2-Pentanol, 4- Methyl-5-Nitroaniline, 2- Methylaniline, N- Methylbenzene-1,4-diamine sulfate, 2- Methylcyclohexane Methylcyclohexylamine, n- Methylcyclopentane Methylene Bromide Methylenebis (2-chloroaniline), 4,4'- Methylnaphthalene, 1- Methylnaphthalene, 2- Methylphenol, 2- Methylphenol, 3- Methylphenol, 4- Midrange Aliphatic Hydrocarbon Streams Monoammonium phosphate (MAP) Monocalcium phosphate (MCP) Monopotassium phosphate Monosodium phosphate Naphtha, High Flash Aromatic (HFAN) Naphthylamine, 2- Neodymium Chloride (Stable, Nonradioactive) Nicotinonitrile Nitroaniline, 2- Nitroaniline, 3- Nitroaniline, 4- Nitrocellulose Nitrodiphenylamine, 2- Nitrofen (technical grade) Nitroglycerin Nitroguanidine Nitromethane Nitrophenol, 2- Nitrophenol, p- Nitropropane, 2- Nitrosodimethylamine, N- Nitrosodiphenylamine, N- Nitrosopyrrolidine, N- Nitrotoluene, m- Nitrotoluene, o- Nitrotoluene, p- Nonane, n- Octadecanoic Acid Octahydrotrimethylmethylethylphenanthrenol Octyl Phthalate, di-N- Pentabromo-6-Chlorocyclohexane, 1,2,3,4,5 Pentachloroethane Pentaerythritol tetranitrate (PETN) Pentamethyl dipropylenetriamine Pentamethylphosphoramide (PMPA) Pentane, n- Perfluorobutanesulfonate Perfluorobutanesulfonic acid (PFBS) Perylene Phenanthrene Phenothiazine Phenyl Isothiocyanate Phenyl-1-(2,4-dimethylphenyl)-ethane, 1- (PXE) Phenylenediamine, o- Phenylenediamine, p- Phosphoric Acid Phosphoric acid, aluminum salt (1:1) [aluminum phosphate] Phosphoric acid, aluminum salt (3:1) [monoaluminum phosphate; aluminum dihydrogenphosphate] Phosphoric acid, aluminum sodium salt (1:X:X) [sodium aluminum phosphate acidic (acidic SALP)] Phosphoric acid, aluminum sodium salt (8:2:3) [sodium aluminum phosphate anhydrous (basic SALP)] Phosphoric acid, aluminum sodium salt (8:3:1) [trialuminum sodium tetra decahydrogenoctaorthophosphate] Phosphoric acid, aluminum sodium salt (8:3:1), tetrahydrate [sodium aluminum phosphate tetrahydrate (SALP)] Phosphorus pentoxide Phthalic Acid, m- Phthalic Acid, o- Phthalic Acid, p- (Terephthalic Acid) Picramic Acid (2-Amino-4,6-dinitrophenol) Picric Acid (2,4,6-Trinitrophenol) Polyphosphoric acid Potassium Perfluorobutane Sulfonate Potassium salts of inorganic phosphates Potassium tripolyphosphate Praseodymium Chloride (Stable, Nonradioactive) Promethium Propionitrile, 3-(NN-dimethylamino) Propyl Alcohol, n- Propylbenzene, n- Propylene Glycol Propylene Glycol Monoethyl Ether, alpha- Propylene Glycol Monoethyl Ether, beta- Prussian Blue (Ferric Ferrocyanide) Pyrene Rubidium Rubidium Chloride Rubidium Hydroxide Rubidium Iodide Samarium Chloride (Stable, Nonradioactive) Samarium Nitrate (Stable, Nonradioactive) Selenourea Sodium Tungstate Sodium Tungstate Dihydrate Sodium acid pyrophosphate Sodium hexametaphosphate Sodium polyphosphate Sodium salts of inorganic phosphates Sodium trimetaphosphate Sodium tripolyphosphate Soluble Antimony Compounds (Antimony Trichloride) Stearyl Acetate Styrene-Acrylonitrile (SAN) Trimer (THNA isomer) Styrene-Acrylonitrile (SAN) Trimer (THNP isomer) Sulfolane Sulfonylbis(4-chlorobenzene), 1,1'- Tetrachlorobenzene, 1,2,4,5- Tetrachloroethane, 1,1,1,2- Tetrachlorotoluene, p- alpha, alpha, alpha- Tetrahydrothiophene Tetramethylcyclohexane Tetramethylphosphoramide, -N,N,N',N'' (TMPA) Tetrapotassium phosphate Tetrasodium pyrophosphate Thallium (I) Nitrate Thallium (Soluble Salts) Thallium Acetate Thallium Carbonate Thallium Chloride Thallium Sulfate Thiocyanates Thiocyanic Acid Thiodiglycol Thiophene Titanium Toluene Toluene-2,5-diamine Toluene-2,5-diamine dihydrochloride Toluene-2,5-diamine monohydrochloride Toluenediamine, 2,3- Toluenediamine, 2,6- Toluenediamine, 3,4- Toluic Acid, p- Toluidine, o- (Methylaniline, 2-) Toluidine, p- Total Petroleum Hydrocarbons (Aliphatic High) Total Petroleum Hydrocarbons (Aliphatic Low) Total Petroleum Hydrocarbons (Aliphatic Medium) Total Petroleum Hydrocarbons (Aromatic High) Total Petroleum Hydrocarbons (Aromatic Low) Total Petroleum Hydrocarbons (Aromatic Medium) Toxaphene, Technical Toxaphene, Weathered Triacetin Tribromophenol, 2,4,6- Tributyl Phosphate Tricaine Methanesulfonate Tricalcium phosphate (TCP) Trichloro-1,2,2-trifluoroethane, 1,1,2- Trichloroaniline, 2,4,6- Trichlorobenzene, 1,2,3- Trichlorobenzene, 1,2,4- Trichloroethane, 1,1,2- Trichlorofluoromethane Trichlorophenol, 2,4,5- Trichlorophenol, 2,4,6- Trichloropropane, 1,1,2- Trichloropropene, 1,2,3- Trichlorotoluene, 2,3,6- Trichlorotoluene, alpha-2,6- Tridymite Triethylene Glycol Trifluoroethane, 1,1,1- Trimethyl Phosphate Trimethyl-4-Propenylnaphthalene, 1,2,3- Trimethylbenzene, 1,2,3- Trimethylbenzene, 1,2,4- Trimethylbenzene, 1,3,5- Trimethylpentene, 2,4,4- Trinitrophenylmethylnitramine (Tetryl) Triphenylphosphine Oxide Triphosphoric acid, aluminum salt (1:1) [aluminum triphosphate] Tripotassium phosphate Tris(1-chloro-2-propyl)phosphate Tris(2-chloroethyl)phosphate Tris(2-ethylhexyl)phosphate Tris(3-chloro-1-propyl)phosphate Trisodium phosphate Tungsten Vanadium Vanadium Pentoxide Vinyl Bromide White Mineral Oil Xylene, Mixture Zirconium Nitroglycerin (CASRN 55-63-0)Chemical Information Chemical Information provided by RAIS PPRTV Derivation Support DocumentPPRTV informationFile Date August 22, 2006 Category Status Oral Chronic RfD On-line Oral Subchronic RfD On-line Inhalation Chronic RfC On-line Inhalation Subchronic RfC On-line Oral Carcinogenicity On-line EPA Cancer Classification On-line Reference Dose for Chronic Oral Exposure (RfD) Effect Level UF RfD Species Route Duration RfD Confidence LOAEL .036 mg/kg-day 300 1E-4 mg/kg-day Human Oral: therapeutic Low-to-medium Target Critical Effect Blood Acute adverse effects related to vasodilation NOTE: LOAEL is the lowest prescribed therapeutic oral dose administered as sustained- or extended-release for 6-8 hours.Principal Study: Katzung and Chatterjee 2001, Kerins et al. 2001Reference Dose for Subchronic Oral Exposure (SRfD) Effect Level UF SRfD Species Route Duration SRfD Confidence LOAEL .036 mg/kg-day 300 1E-4 mg/kg-day Human Oral: therapeutic Low-to-medium Target Critical Effect Blood Acute adverse effects related to vasodilation NOTE: LOAEL is the lowest prescribed therapeutic oral dose administered as sustained- or extended-release for 6-8 hours.Principal Study: Katzung and Chatterjee 2001, Kerins et al. 2001Reference Concentration for Chronic Inhalation Exposure (RfC)NOTE: Data inadequate for deriving a chronic RfC.Reference Concentration for Subchronic Inhalation Exposure (SRfC)NOTE: Data inadequate for deriving a subchronic RfC.Quantitative Estimate of Carcinogenic Risk from Oral Exposure Target Cancer Unit Risk Slope Factor Species Route Duration Liver Hepatocellular tumors 1.7E-2 (mg/kg-day)-1 Rat Oral 24 months NOTE: Based on the LED10Principal Study: Ellis et al. 1984Carcinogenicity Assessment for Lifetime ExposureWeight of Evidence CharacterizationLI - Likely to be carcinogenic to humansReferences U.S. EPA. 2006. Provisional Peer Reviewed Toxicity Values for Nitroglycerin (CASRN 55-63-0). 8-22-2006.
PPRTV Derivation Support Document